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  Asterless is a centriolar protein required for centrosome function and embryo development in Drosophila

Varmark, H., Llamazares, S., Rebollo, E., Lange, B., Reina, J., Schwarz, H., et al. (2007). Asterless is a centriolar protein required for centrosome function and embryo development in Drosophila. Current Biology, 17(20), 1735-1745. doi:10.1016/j.cub.2007.09.031.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-813E-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-813F-A
Genre: Journal Article
Alternative Title : Curr Biol

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 Creators:
Varmark, Hanne, Author
Llamazares, Salud, Author
Rebollo, Elena, Author
Lange, Bodo1, Author              
Reina, Jose, Author
Schwarz, Heinz, Author
Gonzalez, Cayetano, Author
Affiliations:
1Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              

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Free keywords: Cell cycle
 Abstract: Background Centrosomes, the major organizers of the microtubule network in most animal cells, are composed of centrioles embedded in a web of pericentriolar material (PCM). Recruitment and stabilization of PCM on the centrosome is a centriole-dependent function. Compared to the considerable number of PCM proteins known, the molecular characterization of centrioles is still very limited. Only a few centriolar proteins have been identified so far in Drosophila, most related to centriole duplication. Results We have cloned asterless (asl) and found that it encodes a 120 kD highly coiled-coil protein that is a constitutive pancentriolar and basal body component. Loss of asl function impedes the stabilization/maintenance of PCM at the centrosome. In embryos deficient for Asl, development is arrested right after fertilization. Asl shares significant homology with Cep152, a protein described as a component of the human centrosome for which no functional data is yet available. Conclusions The cloning of asl offers new insight into the molecular composition of Drosophila centrioles and a possible model for the role of its human homolog. In addition, the phenotype of asl-deficient flies reveals that a functional centrosome is required for Drosophila embryo development.

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Language(s): eng - English
 Dates: 2007-10-23
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

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Title: Current Biology
  Alternative Title : Curr Biol
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 17 (20) Sequence Number: - Start / End Page: 1735 - 1745 Identifier: ISSN: 0960-9822