English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Expression of Ndufb11 encoding the neuronal protein 15.6 during neurite outgrowth and development.

Gurok, U., Bork, K., Nuber, U., Spörle, R., Nöhring, S., & Horstkorte, R. (2007). Expression of Ndufb11 encoding the neuronal protein 15.6 during neurite outgrowth and development. Mechanisms of Development: Gene Expression Patterns: Gep; A Section of Mechanisms of Development, 7(3), 370-374. doi:10.1016/j.modgep.2006.07.004.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8276-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-8277-F
Genre: Journal Article

Files

show Files
hide Files
:
sdarticle.pdf (Any fulltext), 2MB
 
File Permalink:
-
Name:
sdarticle.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Molecular Genetics, Berlin; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
eDoc_access: MPG
License:
-

Locators

show

Creators

show
hide
 Creators:
Gurok, Ulf1, Author
Bork, Kaya, Author
Nuber, Ulrike2, Author              
Spörle, Ralf3, Author              
Nöhring, Sabine, Author
Horstkorte, Rüdiger, Author
Affiliations:
1Max Planck Society, ou_persistent13              
2Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              
3Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433557              

Content

show
hide
Free keywords: -
 Abstract: Neurite outgrowth (e.g. axonal or dendrite outgrowth) of neurons is necessary for the development and functioning of the central nervous system. It is well accepted that the differentiation of neurons and neurite outgrowth involve alterations in gene expression. Furthermore, mitochondria play a role in different aspects of neurite outgrowth. Here we show that the expression of Ndufb11, a gene encoding the mitochondrial protein NP15.6 is decreased in the course of neuronal differentiation. NP15.6 is homologous to the bovine protein ESSS, a component of the mitochondrial complex 1. The homologous human NDUFB11 gene is localized to Xp11.3–Xp11.23, a region associated with neurogenetic disorders. The down-regulation of NP15.6 correlates with neurite outgrowth of PC12 cells induced by nerve growth factor. Furthermore, we analyzed the expression of Ndufb11 in the embryonic and adult mouse.

Details

show
hide
Language(s): eng - English
 Dates: 2007-01-02
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 337591
DOI: 10.1016/j.modgep.2006.07.004
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Mechanisms of Development: Gene Expression Patterns : Gep ; A Section of Mechanisms of Development
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 7 (3) Sequence Number: - Start / End Page: 370 - 374 Identifier: ISSN: 1567-133X