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Expression of Ndufb11 encoding the neuronal protein 15.6 during neurite outgrowth and development.

MPG-Autoren

Gurok,  Ulf
Max Planck Society;

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Nuber,  Ulrike
Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Spörle,  Ralf
Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Zitation

Gurok, U., Bork, K., Nuber, U., Spörle, R., Nöhring, S., & Horstkorte, R. (2007). Expression of Ndufb11 encoding the neuronal protein 15.6 during neurite outgrowth and development. Mechanisms of Development: Gene Expression Patterns: Gep; A Section of Mechanisms of Development, 7(3), 370-374. doi:10.1016/j.modgep.2006.07.004.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-0010-8276-2
Zusammenfassung
Neurite outgrowth (e.g. axonal or dendrite outgrowth) of neurons is necessary for the development and functioning of the central nervous system. It is well accepted that the differentiation of neurons and neurite outgrowth involve alterations in gene expression. Furthermore, mitochondria play a role in different aspects of neurite outgrowth. Here we show that the expression of Ndufb11, a gene encoding the mitochondrial protein NP15.6 is decreased in the course of neuronal differentiation. NP15.6 is homologous to the bovine protein ESSS, a component of the mitochondrial complex 1. The homologous human NDUFB11 gene is localized to Xp11.3–Xp11.23, a region associated with neurogenetic disorders. The down-regulation of NP15.6 correlates with neurite outgrowth of PC12 cells induced by nerve growth factor. Furthermore, we analyzed the expression of Ndufb11 in the embryonic and adult mouse.