Targeted expression of SHH affects chondrocyte differentiation, growth plate 
organization, and Sox9 expression

Tavella, Sara; Biticchi, Roberta; Schito, Anna; Minina, Eleonora; Di Martino, Davide; Pagano, Aldo; Vortkamp, Andrea; Horton, William A.; Cancedda, Ranieri; Garofalo, Silvio

doi:10.1359/JBMR.040706

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Targeted expression of SHH affects chondrocyte differentiation, growth plate organization, and Sox9 expression

Tavella, S., Biticchi, R., Schito, A., Minina, E., Di Martino, D., Pagano, A., et al. (2004). Targeted expression of SHH affects chondrocyte differentiation, growth plate organization, and Sox9 expression. Journal of Bone and Mineral Research, 19(10), 1678-1688. doi:10.1359/JBMR.040706.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-880E-4 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-880F-2

Genre: Journal Article

Alternative Title : J Bone Miner Res

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Creators:
Tavella, Sara, Author
Biticchi, Roberta, Author
Schito, Anna, Author
Minina, Eleonora¹, Author
Di Martino, Davide, Author
Pagano, Aldo, Author
Vortkamp, Andrea², Author
Horton, William A., Author
Cancedda, Ranieri, Author
Garofalo, Silvio, Author

Affiliations:
1Max Planck Society, ou_persistent13
2Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433554

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Free keywords: rodent animal model; chondrocyte; growth plate; parathyroid hormone/parathyroid hormone-related protein; hedgehog

Abstract: The role of Hedgehogs (Hh) in murine skeletal development was studied by overexpressing human Sonic Hedgehog (SHH) in chondrocytes of transgenic mice using the collagen II promoter/enhancer. Overexpression caused a lethal craniorachischisis with major alterations in long bones because of defects in chondrocyte differentiation.

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Language(s): eng - English

Dates: Date issued: 2004-07-12

Publication Status: Issued

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Identifiers: eDoc: 228617
DOI: 10.1359/JBMR.040706

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Title: Journal of Bone and Mineral Research

Alternative Title : J Bone Miner Res

Source Genre: Journal

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Pages: - Volume / Issue: 19 (10) Sequence Number: - Start / End Page: 1678 - 1688 Identifier: ISSN: 1523-4681