Targeted expression of SHH affects chondrocyte differentiation, growth plate 
organization, and Sox9 expression

Tavella, Sara; Biticchi, Roberta; Schito, Anna; Minina, Eleonora; Di Martino, Davide; Pagano, Aldo; Vortkamp, Andrea; Horton, William A.; Cancedda, Ranieri; Garofalo, Silvio

doi:10.1359/JBMR.040706

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Targeted expression of SHH affects chondrocyte differentiation, growth plate organization, and Sox9 expression

MPS-Authors

Minina, Eleonora
Max Planck Society;

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Vortkamp, Andrea
Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society;

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引用

Tavella, S., Biticchi, R., Schito, A., Minina, E., Di Martino, D., Pagano, A., Vortkamp, A., Horton, W. A., Cancedda, R., & Garofalo, S. (2004). Targeted expression of SHH affects chondrocyte differentiation, growth plate organization, and Sox9 expression. Journal of Bone and Mineral Research, 19(10), 1678-1688. doi:10.1359/JBMR.040706.

引用: https://hdl.handle.net/11858/00-001M-0000-0010-880E-4

要旨

The role of Hedgehogs (Hh) in murine skeletal development was studied by overexpressing human Sonic Hedgehog (SHH) in chondrocytes of transgenic mice using the collagen II promoter/enhancer. Overexpression caused a lethal craniorachischisis with major alterations in long bones because of defects in chondrocyte differentiation.