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  Interactive rhythmic auditory stimulation reinstates natural 1/f timing in gait of Parkinson's patients

Hove, M. J., Suzuki, K., Uchitomi, H., Orimo, S., & Miyake, Y. (2012). Interactive rhythmic auditory stimulation reinstates natural 1/f timing in gait of Parkinson's patients. PLoS One, 7(3): e32600. doi:10.1371/journal.pone.0032600.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-B893-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-CFB2-B
Genre: Journal Article

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 Creators:
Hove, Michael J.1, 2, Author              
Suzuki, Kazuki2, Author
Uchitomi, Hirotaka2, Author
Orimo, Satoshi3, Author
Miyake, Yoshihiro2, Author
Affiliations:
1Max Planck Research Group Music Cognition and Action, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634555              
2Department of Computational Intelligence and Systems Science, Tokyo Institute of Technology, Yokohama, Japan, ou_persistent22              
3Department of Neurology, Kanto Central Hospital, Tokyo, Japan, ou_persistent22              

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 Abstract: Parkinson's disease (PD) and basal ganglia dysfunction impair movement timing, which leads to gait instability and falls. Parkinsonian gait consists of random, disconnected stride times—rather than the 1/f structure observed in healthy gait—and this randomness of stride times (low fractal scaling) predicts falling. Walking with fixed-tempo Rhythmic Auditory Stimulation (RAS) can improve many aspects of gait timing; however, it lowers fractal scaling (away from healthy 1/f structure) and requires attention. Here we show that interactive rhythmic auditory stimulation reestablishes healthy gait dynamics in PD patients. In the experiment, PD patients and healthy participants walked with a) no auditory stimulation, b) fixed-tempo RAS, and c) interactive rhythmic auditory stimulation. The interactive system used foot sensors and nonlinear oscillators to track and mutually entrain with the human's step timing. Patients consistently synchronized with the interactive system, their fractal scaling returned to levels of healthy participants, and their gait felt more stable to them. Patients and healthy participants rarely synchronized with fixed-tempo RAS, and when they did synchronize their fractal scaling declined from healthy 1/f levels. Five minutes after removing the interactive rhythmic stimulation, the PD patients' gait retained high fractal scaling, suggesting that the interaction stabilized the internal rhythm generating system and reintegrated timing networks. The experiment demonstrates that complex interaction is important in the (re)emergence of 1/f structure in human behavior and that interactive rhythmic auditory stimulation is a promising therapeutic tool for improving gait of PD patients.

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Language(s): eng - English
 Dates: 2011-10-062012-01-272012-03-02
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1371/journal.pone.0032600
PMID: 22396783
PMC: PMC3292577
Other: Epub 2012
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 7 (3) Sequence Number: e32600 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850