English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  IntScore: a web tool for confidence scoring of biological interactions

Kamburov, A., Stelzl, U., & Herwig, R. (2012). IntScore: a web tool for confidence scoring of biological interactions. Nucleic Acids Research (London), 40(Web Server issue), W140-W146. doi:10.1093/nar/gks492.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-E7B0-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-000E-E7B1-A
Genre: Journal Article

Files

show Files
hide Files
:
Kamburov.pdf (Publisher version), 4MB
Name:
Kamburov.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
© 2012 Oxford University Press
License:
-

Locators

show

Creators

show
hide
 Creators:
Kamburov, Atanas1, Author              
Stelzl, Ulrich2, Author              
Herwig, Ralf1, Author              
Affiliations:
1Bioinformatics (Ralf Herwig), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479648              
2Molecular Interaction Networks (Ulrich Stelzl), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479660              

Content

show
hide
Free keywords: *Gene Regulatory Networks Internet Protein Interaction Mapping/*methods *Software
 Abstract: Knowledge of all molecular interactions that potentially take place in the cell is a key for a detailed understanding of cellular processes. Currently available interaction data, such as protein-protein interaction maps, are known to contain false positives that inevitably diminish the accuracy of network-based inferences. Interaction confidence scoring is thus a crucial intermediate step after obtaining interaction data and before using it in an interaction network-based inference approach. It enables to weight individual interactions according to the likelihood that they actually take place in the cell, and can be used to filter out false positives. We describe a web tool called IntScore which calculates confidence scores for user-specified sets of interactions. IntScore provides six network topology- and annotation-based confidence scoring methods. It also enables the integration of scores calculated by the different methods into an aggregate score using machine learning approaches. IntScore is user-friendly and extensively documented. It is freely available at http://intscore.molgen.mpg.de.

Details

show
hide
Language(s): eng - English
 Dates: 2012-05-302012-07
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1093/nar/gks492
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Nucleic Acids Research (London)
  Other : Nucleic Acids Res
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Oxford : Oxford University Press
Pages: - Volume / Issue: 40 (Web Server issue) Sequence Number: - Start / End Page: W140 - W146 Identifier: ISSN: 0305-1048
CoNE: /journals/resource/110992357379342