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  High-resolution MRI and diffusion-weighted imaging of the human habenula at 7 tesla

Strotmann, B., Heidemann, R. M., Anwander, A., Weiss, M., Trampel, R., Villringer, A., et al. (2014). High-resolution MRI and diffusion-weighted imaging of the human habenula at 7 tesla. Journal of Magnetic Resonance Imaging, 39(4), 1018-1026. doi:10.1002/jmri.24252.

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 Urheber:
Strotmann, Barbara1, Autor           
Heidemann, Robin M.1, 2, Autor           
Anwander, Alfred3, Autor           
Weiss, Marcel1, Autor           
Trampel, Robert1, Autor           
Villringer, Arno4, Autor           
Turner, Robert1, Autor           
Affiliations:
1Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
2Siemens Sector Healthcare, Erlangen, Germany, ou_persistent22              
3Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Schlagwörter: Habenula; 7T; Structural MRI; Diffusion-weighted imaging
 Zusammenfassung: Purpose

To investigate the feasibility of discriminating the habenula in human brain using high-resolution structural MRI and diffusion-weighted imaging at 7 Tesla (T).
Materials and Methods

MRI experiments included a MP2RAGE and GRE sequence to acquire quantitative parameter maps of T1, T2*, and a calculated proton density map and the combined approach of zoomed and parallel imaging (ZOOPPA) to obtain dw images. Probabilistic tractography algorithms were used to identify multiple fiber orientations in submillimetre voxels, and constrained spherical deconvolution to resolve orientations in regions where fibers cross.
Results

Maps of T1, T2*, and proton density showed high contrast of the human habenula. The lateral habenula and its commissure can be distinguished from medial habenula and adjacent tissue. DWI data with 0.7 mm isotropic resolution revealed that fiber populations differ in medial and lateral habenula and two major fiber bundles that connect habenular nuclei with forebrain structures and brainstem.
Conclusion

High resolution 7T MR imaging of the human habenula provides sufficient signal-to-noise and contrast to enable identification of the lateral and medial nuclei. In vivo high resolution DWI at 7T is able to distinguish between lateral and medial habenula, and to detect major fiber tracts that connect the habenula with other brain areas.

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Sprache(n): eng - English
 Datum: 2013-01-212013-05-092013-11-202014-04
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1002/jmri.24252
PMID: 24259421
Anderer: Epub 2013
 Art des Abschluß: -

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Titel: Journal of Magnetic Resonance Imaging
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: Chicago, IL : Society for Magnetic Resonance Imaging
Seiten: - Band / Heft: 39 (4) Artikelnummer: - Start- / Endseite: 1018 - 1026 Identifikator: ISSN: 1053-1807
CoNE: https://pure.mpg.de/cone/journals/resource/954925594512