English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Evaluation of the potential of nonlinear gradients for separating a ternary mixture

Damtew Hamza, A., Sreedhar, B., & Seidel-Morgenstern, A. (2009). Evaluation of the potential of nonlinear gradients for separating a ternary mixture. Journal of Chromatography A, 1216(28), 5355-5364. doi:10.1016/j.chroma.2009.05.026.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-9389-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0026-DB52-8
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Damtew Hamza, Andualem1, 2, Author              
Sreedhar, B.2, 3, Author              
Seidel-Morgenstern, A.1, 2, Author              
Affiliations:
1Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              
2Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
3International Max Planck Research School (IMPRS), Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, DE, ou_1738143              

Content

show
hide
Free keywords: Preparative gradient elution chromatography; Nonlinear gradients; Craig model; Optimization
 Abstract: The potential of applying nonlinear gradients in preparative chromatography is evaluated theoretically and experimentally. The second eluting component of a ternary model mixture is considered as the target component. Systematic gradient resolution experiments were conducted for this mixture using reversed phase chromatography. In preliminary experimental investigations the effect of the mobile phase composition on the specific distribution equilibria was quantified. Concave and convex solvent strength gradients were analysed and compared with conventional linear gradients. Main result of the study is the fact that significant improvement in productivity can be achieved if the gradient shapes are designed carefully. Copyright © 2009 Elsevier B.V. All rights reserved. [accessed July 27, 2009]

Details

show
hide
Language(s): eng - English
 Dates: 2009
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 433493
DOI: 10.1016/j.chroma.2009.05.026
Other: 52/09
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Chromatography A
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 1216 (28) Sequence Number: - Start / End Page: 5355 - 5364 Identifier: ISSN: 0021-9673