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  Simultaneous single-quantum and triple-quantum-filtered MRI of 23Na (SISTINA)

Fiege, D., Romanzetti, S., Mirkes, C., Brenner, D., & Shah, N. (2013). Simultaneous single-quantum and triple-quantum-filtered MRI of 23Na (SISTINA). Magnetic Resonance in Medicine, 69(6), 1691-1696. doi:10.1002/mrm.24417.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-B6BA-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-1E41-5
Genre: Journal Article

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Fiege, DP, Author
Romanzetti, S, Author
Mirkes, C1, Author              
Brenner, D, Author
Shah, NJ, Author
Affiliations:
1Institute of Neuroscience and Medicine, Forschungszentrum Jülich, ou_persistent22              

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 Abstract: The low MR sensitivity of the sodium nucleus and its low concentration in the human body constrain acquisition time. The use of both single-quantum and triple-quantum sodium imaging is, therefore, restricted. In this work, we present a novel MRI sequence that interleaves an ultra-short echo time radial projection readout into the three-pulse triple-quantum preparation. This allows for simultaneous acquisition of tissue sodium concentration weighted as well as triple-quantum filtered images. Performance of the sequence is shown on phantoms. The method is demonstrated on six healthy informed volunteers and is applied to three cases of brain tumors. A comparison with images from tumor specific O-(2-[18F]fluoroethyl)-L-tyrosine positron emission tomography and standard MR images is presented. The combined information of the triple-quantum-filtered images with single-quantum images may enable a better understanding of tissue viability. Future studies can benefit from the evaluation of both contrasts with shortened acquisition times.

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 Dates: 2012-072013-06
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/mrm.24417
BibTex Citekey: FiegeRMBS2012
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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Pages: - Volume / Issue: 69 (6) Sequence Number: - Start / End Page: 1691 - 1696 Identifier: -