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  Cation-Responsive MRI Contrast Agents Based on Gadolinium(III)

Angelovski, G., & Mamedov, I. (2011). Cation-Responsive MRI Contrast Agents Based on Gadolinium(III). Current Inorganic Chemistry, 1(1), 76-90. doi:10.2174/1877944111101010076.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-BBA6-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-AA9B-E
Genre: Journal Article

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http://www.eurekaselect.com/95767/article (Publisher version)
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 Creators:
Angelovski, G1, 2, Author              
Mamedov, I1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Magnetic resonance imaging (MRI) offers the ability to visualize a number of biological processes at the molecular and cellular level. The quest for MRI methods that enable the monitoring of these processes with improved specificity and spatiotemporal resolution has induced a considerable amount of research into the chemistry of contrast agents. A novel class of agents has been developed that is able to report a change in its magnetic properties as a function of a specific parameter in the surrounding microenvironment. The vast majority consist of paramagnetic Gd3+ complexes that enhance the contrast in the MR image upon a change in the local concentration of a biologically relevant ion, such as H+, Ca2+, Zn2+, or Cu2+. This review summarizes their coordination chemistry and further aspects of these responsive paramagnetic complexes and discusses the most recent examples that are described in the literature.

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 Dates: 2011-05
 Publication Status: Published in print
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 Identifiers: DOI: 10.2174/1877944111101010076
BibTex Citekey: AngelovskiM2011
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Title: Current Inorganic Chemistry
Source Genre: Journal
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Pages: - Volume / Issue: 1 (1) Sequence Number: - Start / End Page: 76 - 90 Identifier: -