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  Relaxometric, Thermodynamic and Kinetic Studies of Lanthanide(III) Complexes of DO3A-Based Propylphosphonates

Mamedov, I., Táborský, P., Lubal, P., Laurent, S., Elst, L., Mayer, H., et al. (2009). Relaxometric, Thermodynamic and Kinetic Studies of Lanthanide(III) Complexes of DO3A-Based Propylphosphonates. European Journal of Inorganic Chemistry, 2009(22), 3298-3306. doi:10.1002/ejic.200900149.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-C36F-A Version Permalink: http://hdl.handle.net/21.11116/0000-0002-BE4E-2
Genre: Journal Article

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Mamedov, I1, 2, Author              
Táborský , P, Author
Lubal, P, Author
Laurent, S, Author
Elst, LV, Author
Mayer, HA, Author
Logothetis, NK1, 2, Author              
Angelovski, G1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Two DO3A-based ligands appended with the propylphosphonate side arm and their Ln3+ complexes were investigated. Proton relaxometric in vitro studies at 20 MHz and 60 MHz and 37 °C of the Gd3+ complex containing free acid exhibited relative changes of up to 56 in r1 relaxivity when the pH of the medium was changed from 4 to 7. This change is explained by the decrease in the number of coordinated water molecules from two to one. Temperature-dependent relaxivity and NMRD profiles of Gd3+ complexes showed a fast water exchange and a slightly increased rotational correlation time, which is characteristic of phosphonate-containing compounds. Thermodynamic and kinetic studies of the Gd3+ and Eu3+ complexes were performed by means of potentiometry and luminescence spectroscopy. The results indicate that the thermodynamic stability and kinetic inertness of these complexes are sufficient for their in vivo application.

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 Dates: 2009-08
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: DOI: 10.1002/ejic.200900149
BibTex Citekey: 5963
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Title: European Journal of Inorganic Chemistry
  Abbreviation : Eur. J. Inorg. Chem.
Source Genre: Journal
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Publ. Info: Weinheim, Germany : Wiley-VCH
Pages: - Volume / Issue: 2009 (22) Sequence Number: - Start / End Page: 3298 - 3306 Identifier: ISSN: 1434-1948
CoNE: https://pure.mpg.de/cone/journals/resource/954926953810_1