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  Azamacrocyclic Ca2+ Sensitive Contrast Agents for MR Imaging

Mamedov, I., Angelovski, G., Henig, J., Mayer, H., & Logothetis, N. (2007). Azamacrocyclic Ca2+ Sensitive Contrast Agents for MR Imaging. Poster presented at AMI/SMI Joint Molecular Imaging Conference 2007, Providence, RI, USA.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-CC13-A Version Permalink: http://hdl.handle.net/21.11116/0000-0003-F3F4-7
Genre: Poster

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SMI-2007-Mamedov.pdf (Any fulltext), 18KB
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 Creators:
Mamedov, I1, 2, Author              
Angelovski, G1, 2, Author              
Henig, J, Author
Mayer, HA, Author
Logothetis, NK1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: As calcium plays an important role in regulating a great variety of neuronal processes, many efforts are already made to generate gadolinium complexes that can act as a calcium-sensors in MRI.1 We developed a series of the DO3A-based macrocyclic and bismacrocyclic gadolinium chelates, bearing phosphonate groups as an additional coordination sites. These complexes are hypothesized to change the MRI contrast dynamically with Ca2+ concentration. Different lengths of the phosphonate side chains are exploited for fine-tuning the sensitivity of the agent to calcium ion concentration.

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 Dates: 2007-09
 Publication Status: Published online
 Pages: -
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 Identifiers: BibTex Citekey: 4816
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Title: AMI/SMI Joint Molecular Imaging Conference 2007
Place of Event: Providence, RI, USA
Start-/End Date: 2007-09-08 - 2007-09-11

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