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Abstract:
The effect of a dermorphin analog on learning was studied in a Wistar rat model of the complex food-seeking task. The preparation decreased the degree of anxiety in a dose-independent manner. In a dose of 50 μg/kg it increased the number of “well”-learning rats by intensifying the learning process in rats with initially suppressed cognitive activity. In a dose of 150 μg/kg, the opioid decreased the number of “well”-learning rats due to disturbance of motivation mechanisms, which was manifested in behavioral instability.
