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  In vivo MRI analysis of depth-dependent ultrastructure in human knee cartilage at 7 T

Garnov, N., Gründer, W., Thörmer, G., Trampel, R., Turner, R., Kahn, T., et al. (2013). In vivo MRI analysis of depth-dependent ultrastructure in human knee cartilage at 7 T. NMR in Biomedicine, 26(11), 1412-1419. doi:10.1002/nbm.2968.

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 Creators:
Garnov, Nikita1, Author
Gründer, Wilfried2, Author
Thörmer, Gregor1, Author
Trampel, Robert3, Author              
Turner, Robert3, Author              
Kahn, Thomas1, Author
Busse, Harald1, Author
Affiliations:
1Department of Diagnostic and Interventional Radiology, University Hospital Leipzig, Germany, ou_persistent22              
2Department of Medical Physics and Biophysics, University of Leipzig, Germany, ou_persistent22              
3Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              

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Free keywords: Hyaline cartilage; Cartilage fiber structure; Angle-sensitive MRI; Age dependency; 7 T MRI
 Abstract: Signal intensities of T2-weighted magnetic resonance images depend on the local fiber arrangement in hyaline cartilage. The aims of this study were to determine whether angle-sensitive MRI at 7 T can be used to quantify the cartilage ultrastructure of the knee in vivo and to assess potential differences with age. Ten younger (21–30 ) and ten older (55–76 years old) healthy volunteers were imaged with a T2-weighted spin-echo sequence in a 7 T whole-body MRI. A “fascicle” model was assumed to describe the depth-dependent fiber arrangement of cartilage. The R/T boundary positions between radial and transitional zones were assessed from intensity profiles in small regions of interest in the femur and tibia, and normalized to cartilage thickness using logistic curve fits. The quality of our highly resolved (0.3 × 0.3 × 1.0 mm3) MR cartilage images were high enough for quantitative analysis (goodness of fit R2 = 0.91 ± 0.09). Between younger and older subjects, normalized positions of the R/T boundary, with value 0 at the bone–cartilage interface and 1 at the cartilage surface, were significantly (p < 0.05) different in femoral (0.51 ± 0.12 versus 0.41 ± 0.10), but not in tibial cartilage (0.65 ± 0.11 versus 0.57 ± 0.09, p = 0.119). Within both age groups, differences between femoral and tibial R/T boundaries were significant. Using a fascicle model and angle-sensitive MRI, the depth-dependent anisotropic fiber arrangement of knee cartilage could be assessed in vivo from a single 7 T MR image. The derived quantitative parameter, thickness of the radial zone, may serve as an indicator of the structural integrity of cartilage. This method may potentially be suitable to detect and monitor early osteoarthritis because the progressive disintegration of the anisotropic network is also indicative of arthritic changes in cartilage.

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Language(s): eng - English
 Dates: 2013-02-262012-11-292013-04-012013-06-252013-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/nbm.2968
PMID: 23801556
Other: Epub 2013
 Degree: -

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Title: NMR in Biomedicine
Source Genre: Journal
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Pages: - Volume / Issue: 26 (11) Sequence Number: - Start / End Page: 1412 - 1419 Identifier: ISSN: 0952-3480
CoNE: https://pure.mpg.de/cone/journals/resource/954925574973