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  High-resolution MR imaging of the human brainstem in vivo at 7 Tesla

Deistung, A., Schäfer, A., Schweser, F., Biedermann, U., Güllmar, D., Trampel, R., et al. (2013). High-resolution MR imaging of the human brainstem in vivo at 7 Tesla. Frontiers in Human Neuroscience, 7: 710. doi:10.3389/fnhum.2013.00710.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-6192-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-9E8D-D
Genre: Journal Article

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 Creators:
Deistung, Andreas1, Author
Schäfer, Andreas2, Author              
Schweser, Ferdinand1, Author
Biedermann, Uta3, Author
Güllmar, Daniel1, Author
Trampel, Robert2, Author              
Turner, Robert2, Author              
Reichenbach, Jürgen R.1, Author
Affiliations:
1Medical Physics Group, Department of Radiology, Friedrich Schiller University Jena, Germany, ou_persistent22              
2Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
3Institute of Anatomy, Jena University Hospital, Germany, ou_persistent22              

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Free keywords: Brainstem; Quantitative susceptibility mapping; Longitudinal relaxation; Effective transverse relaxation; Diffusion tensor imaging; Track density imaging; Anatomysusceptibility; QSM; 7 Tesla; Brainstem; T1; T2*
 Abstract: The human brainstem, which comprises a multitude of axonal nerve fibers and nuclei, plays an important functional role in the human brain. Depicting its anatomy non-invasively with high spatial resolution may thus in turn help to better relate normal and pathological anatomical variations to medical conditions as well as neurological and peripheral functions. We explored the potential of high-resolution magnetic resonance imaging (MRI) at 7T for depicting the intricate anatomy of the human brainstem in vivo by acquiring and generating images with multiple contrasts: T2-weighted images, quantitative maps of longitudinal relaxation rate (R1-maps) and effective transverse relaxation rate (R2*-maps), magnetic susceptibility maps, and direction-encoded track-density images. Images and quantitative maps were compared with histological stains and anatomical atlases to identify nerve nuclei and nerve fibers. Among the investigated contrasts, susceptibility maps displayed the largest number of brainstem structures. Contrary to R1 maps and T2-weighted images, which showed rather homogeneous contrast, R2* maps, magnetic susceptibility maps and track-density images clearly displayed a multitude of smaller and larger fiber bundles. Several brainstem nuclei were identifiable in sections covering the pons and medulla oblongata, including the spinal trigeminal and the reticulotegmental nucleus on magnetic susceptibility maps as well as the inferior olive on R1, R2*, and susceptibility maps. The substantia nigra and red nuclei were visible in all contrasts. In conclusion, high-resolution, multi-contrast MR imaging at 7 Tesla is a versatile tool to non-invasively assess the individual anatomy and tissue composition of the human brainstem.

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Language(s): eng - English
 Dates: 2013-05-302013-10-072013-10-29
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3389/fnhum.2013.00710
PMID: 24194710
PMC: PMC3810670
Other: eCollection 2013
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Title: Frontiers in Human Neuroscience
  Abbreviation : Front Hum Neurosci
Source Genre: Journal
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Pages: - Volume / Issue: 7 Sequence Number: 710 Start / End Page: - Identifier: ISSN: 1662-5161
CoNE: https://pure.mpg.de/cone/journals/resource/1662-5161