非表示:
キーワード:
azide; dienes; electrocyclic; allylic alkylation; bioconjugation
要旨:
We report an atom-economical domino synthesis of functionalized and stereodefined dienes. This method hinges on an allylic alkylation–electrocyclic ring-opening sequence and allows direct access to doubly vinylogous azido-dienoic acids bearing challenging substitution patterns. This class of compounds represents useful linkers in chemical biology by virtue of the orthogonality between the azido and carboxylic acid moieties.