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  Increased functional connectivity between prefrontal cortex and reward system in pathological gambling

Koehler, S., Ovadia-Caro, S., van der Meer, E., Villringer, A., Heinz, A., Romanczuk-Seiferth, N., et al. (2013). Increased functional connectivity between prefrontal cortex and reward system in pathological gambling. PLoS One, 8(12): e84565. doi:10.1371/journal.pone.0084565.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-CF78-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-9E8A-0
Genre: Journal Article

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Koehler, Saskia1, 2, 3, 4, Author
Ovadia-Caro, Smadar1, 3, 4, Author              
van der Meer, Elke1, 3, Author
Villringer, Arno1, 4, Author              
Heinz, Andreas1, 2, Author
Romanczuk-Seiferth, Nina2, Author
Margulies, Daniel S.1, 4, Author              
Affiliations:
1Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
2Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
3Department of Cognitive Psychology, Humboldt University Berlin, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              

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 Abstract: Pathological gambling (PG) shares clinical characteristics with substance-use disorders and is thus discussed as a behavioral addiction. Recent neuroimaging studies on PG report functional changes in prefrontal structures and the mesolimbic reward system. While an imbalance between these structures has been related to addictive behavior, whether their dysfunction in PG is reflected in the interaction between them remains unclear. We addressed this question using functional connectivity resting-state fMRI in male subjects with PG and controls. Seed-based functional connectivity was computed using two regions-of-interest, based on the results of a previous voxel-based morphometry study, located in the prefrontal cortex and the mesolimbic reward system (right middle frontal gyrus and right ventral striatum). PG patients demonstrated increased connectivity from the right middle frontal gyrus to the right striatum as compared to controls, which was also positively correlated with nonplanning aspect of impulsiveness, smoking and craving scores in the PG group. Moreover, PG patients demonstrated decreased connectivity from the right middle frontal gyrus to other prefrontal areas as compared to controls. The right ventral striatum demonstrated increased connectivity to the right superior and middle frontal gyrus and left cerebellum in PG patients as compared to controls. The increased connectivity to the cerebellum was positively correlated with smoking in the PG group. Our results provide further evidence for alterations in functional connectivity in PG with increased connectivity between prefrontal regions and the reward system, similar to connectivity changes reported in substance use disorder.

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Language(s): eng - English
 Dates: 2013-08-032013-11-152013-12-19
 Publication Status: Published online
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.pone.0084565
PMID: 24367675
PMC: PMC3868704
Other: eCollection 2013
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 8 (12) Sequence Number: e84565 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850