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  Remote control - triggering of brain autoimmune disease in the gut

Wekerle, H., Berer, K., & Krishnamoorthy, G. (2013). Remote control - triggering of brain autoimmune disease in the gut. CURRENT OPINION IN IMMUNOLOGY, 25(6), 683-689. doi:10.1016/j.coi.2013.09.009.

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 Creators:
Wekerle, Hartmut1, Author           
Berer, Kerstin1, Author           
Krishnamoorthy, Gurumoorthy1, Author           
Affiliations:
1Emeritus Group: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society, ou_1113547              

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Free keywords: MYELIN BASIC-PROTEIN; REGULATORY T-CELLS; SEGMENTED FILAMENTOUS BACTERIA; MULTIPLE-SCLEROSIS PATIENTS; PATHOGENIC T(H)17 CELLS; CENTRAL-NERVOUS-SYSTEM; COMMENSAL MICROBIOTA; B-CELLS; INTESTINAL HOMEOSTASIS; DENDRITIC CELL
 Abstract: Converging evidence indicates that multiple sclerosis, an inflammatory dennyelinating disease of the central nervous system, is caused by brain-specific, self-reactive T lymphocytes. These are normal components embedded in the human immune system throughout healthy life. Only upon activation in the periphery, the T cells assume properties that enable them to breakthrough the vascular blood-brain barrier and to invade the brain white matter. While activation has been traditionally associated with microbial infections, recently, studies of animal models revealed a critical role of the commensal gut flora as a key triggering factor. These findings may pave the way to new strategies to treat MS and other human autoimmune diseases, and commend a reevaluation of dietary approaches.

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Language(s): eng - English
 Dates: 2013-12
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000328719900004
DOI: 10.1016/j.coi.2013.09.009
 Degree: -

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Title: CURRENT OPINION IN IMMUNOLOGY
  Other : SI: Autoimmunity * Allergy and hypersensitivity
Source Genre: Journal
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Publ. Info: 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND : CURRENT BIOLOGY LTD
Pages: - Volume / Issue: 25 (6) Sequence Number: - Start / End Page: 683 - 689 Identifier: ISSN: 0952-7915