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  Struggling to let go: A non‐coding RNA directs its own extension and destruction

Bernecky, C., & Cramer, P. (2013). Struggling to let go: A non‐coding RNA directs its own extension and destruction. EMBO Journal, 32(6), 771-772. doi:10.1038/emboj.2013.36.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0015-3C73-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-08D1-9
Genre: Journal Article

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1922717.pdf (Publisher version), 83KB
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http://emboj.embopress.org/content/32/6/771 (Publisher version)
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 Creators:
Bernecky, C., Author
Cramer, P.1, Author              
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1Department of Molecular Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1863498              

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 Abstract: In addition to its role in DNA-dependent transcription, RNA polymerase II (Pol II) possesses RNA-dependent RNA polymerase (RdRP) activity (Lehmann et al, 2007). In a study published in this issue of The EMBO Journal, Wagner et al (2013) report the first native cellular function of the RdRP activity of Pol II. The authors find that a mammalian non-coding RNA (ncRNA) can serve as a template for its own extension by Pol II, resulting in its destabilization and a decrease in its potency to repress Pol II.

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Language(s): eng - English
 Dates: 2013-02-20
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: DOI: 10.1038/emboj.2013.36
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Title: EMBO Journal
Source Genre: Journal
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Pages: - Volume / Issue: 32 (6) Sequence Number: - Start / End Page: 771 - 772 Identifier: -