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Free keywords:
gene transcription and regulation; integrated
structural biology; molecular systems biology; RNA
polymerase; yeast
Abstract:
Ten years after the determination of the RNA polymerase II
structure, the basic mechanism of mRNA synthesis during
gene transcription is known. In the future, the initiation and
regulation of transcription must be studied with a combination
of structural biology, biochemistry, functional genomics,
and computational methods. In this article, the efforts of our
laboratory to move from an integrated structural biology of
gene transcription towards molecular systems biology of
gene regulation are reviewed.
