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  Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95

Kornau, H. C., Schenker, L. T., Kennedy, M. B., & Seeburg, P. H. (1995). Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science, 269(5231), 1737-1740. doi:10.1126/science.7569905.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-A791-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-ADE9-8
Genre: Journal Article

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Science_269_1995_1737.pdf (Any fulltext), 2MB
 
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 Creators:
Kornau, Hans Christian1, Author              
Schenker, Leslie T., Author
Kennedy, Mary B., Author
Seeburg, Peter H.1, Author              
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1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: The N-methyl-D-aspartate (NMDA) receptor subserves synaptic glutamate-induced transmission and plasticity in central neurons. The yeast two-hybrid system was used to show that the cytoplasmic tails of NMDA receptor subunits interact with a prominent postsynaptic density protein PSD-95. The second PDZ domain in PSD-95 binds to the seven-amino acid, COOH-terminal domain containing the terminal tSXV motif (where S is serine, X is any amino acid, and V is valine) common to NR2 subunits and certain NR1 splice forms. Transcripts encoding PSD-95 are expressed in a pattern similar to that of NMDA receptors, and the NR2B subunit co-localizes with PSD-95 in cultured rat hippocampal neurons. The interaction of these proteins may affect the plasticity of excitatory synapses.

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Language(s): eng - English
 Dates: 1995-06-081995-08-071995-09-22
 Publication Status: Published in print
 Pages: 4
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 Rev. Method: Peer
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Title: Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 269 (5231) Sequence Number: - Start / End Page: 1737 - 1740 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1