English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
 Local TagsRelease HistoryDetailsSummary
  Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95

Kornau, H. C., Schenker, L. T., Kennedy, M. B., & Seeburg, P. H. (1995). Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science, 269(5231), 1737-1740. doi:10.1126/science.7569905.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0019-A791-C Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002D-ADE9-8
Genre: Journal Article

Files

show Files
hide Files
:
Science_269_1995_1737.pdf (Any fulltext), 2MB
 
File Permalink:
-
Name:
Science_269_1995_1737.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Locator:
http://science.sciencemag.org/content/269/5231/1737/tab-pdf (Any fulltext)
Description:
-
OA-Status:
Locator:
https://doi.org/10.1126/science.7569905 (Any fulltext)
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Kornau, Hans Christian1, Author           
Schenker, Leslie T., Author
Kennedy, Mary B., Author
Seeburg, Peter H.1, Author           
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

Content

show
hide
Free keywords: -
 Abstract: The N-methyl-D-aspartate (NMDA) receptor subserves synaptic glutamate-induced transmission and plasticity in central neurons. The yeast two-hybrid system was used to show that the cytoplasmic tails of NMDA receptor subunits interact with a prominent postsynaptic density protein PSD-95. The second PDZ domain in PSD-95 binds to the seven-amino acid, COOH-terminal domain containing the terminal tSXV motif (where S is serine, X is any amino acid, and V is valine) common to NR2 subunits and certain NR1 splice forms. Transcripts encoding PSD-95 are expressed in a pattern similar to that of NMDA receptors, and the NR2B subunit co-localizes with PSD-95 in cultured rat hippocampal neurons. The interaction of these proteins may affect the plasticity of excitatory synapses.

Details

show
hide
Language(s): eng - English
 Dates: 1995-06-081995-08-071995-09-22
 Publication Status: Issued
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 666743
DOI: 10.1126/science.7569905
URI: https://www.ncbi.nlm.nih.gov/pubmed/7569905
Other: 4163
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Science
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 269 (5231) Sequence Number: - Start / End Page: 1737 - 1740 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1