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Free keywords:
enzyme inhibitors; gold; medicinal chemistry; platinum; structure elucidation
Abstract:
Redox-based chemotherapy: The irreversible inhibition of human glutathione reductase results in a unique S-AuI-S coordination, which was determined crystallographically. The chemotherapeutic potential of phosphine–metal complexes was probed by kinetic analysis of the fast and effective inhibition of redox enzymes as well as by DNA-interaction studies and cell-proliferation tests.