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  Fast manipulation of cellular cAMP level by light in vivo

Schröder-Lang, S., Schwärzel, M., Seifert, R., Strünker, T., Kateriya, S., Looser, J., et al. (2007). Fast manipulation of cellular cAMP level by light in vivo. Nature Methods, 4(1), 39-42. doi:10.1038/nmeth975.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-D89F-C Version Permalink: https://hdl.handle.net/21.11116/0000-0007-4A51-B
Genre: Journal Article

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Schröder-Lang, Saskia1, Author           
Schwärzel, Martin2, Author
Seifert, Reinhard3, Author
Strünker, Timo3, Author
Kateriya, Suneel4, Author
Looser, Jens5, Author
Watanabe, Masakatsu6, 7, Author
Kaupp, Benjamin3, Author
Hegemann, Peter4, Author
Nagel, Georg1, 5, Author           
Affiliations:
1Department of Biophysical Chemistry, Max Planck Institute of Biophysics, Max Planck Society, ou_2068289              
2Saarland Universität, Naturwissenschaftlich-Technische Fakultät III, FR 8.3, Zoologie & Physiologie, 66041 Saarbrücken, Germany, ou_persistent22              
3Abteilung Zelluläre Signalverarbeitung, Forschungszentrum Jülich, Institut für Neurowissenschaften und Biophysik, INB-1, 52425 Jülich, Germany, ou_persistent22              
4Humboldt Universität zu Berlin, Experimentelle Biophysik, 10115 Berlin, Germany, ou_persistent22              
5Universität Würzburg, Julius-von-Sachs-Institut für Biowissenschaften, Würzburg, 97082, Germany, ou_persistent22              
6National Institute for Basic Biology, Okazaki, 444-8585, Japan, ou_persistent22              
7School of Advanced Sciences, Graduate University of Advanced Studies (SOKENDAI), Hayama, 240-0193, Japan, ou_persistent22              

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 Abstract: The flagellate Euglena gracilis contains a photoactivated adenylyl cyclase (PAC), consisting of the flavoproteins PACα and PACβ. Here we report functional expression of PACs in Xenopus laevis oocytes, HEK293 cells and in Drosophila melanogaster, where neuronal expression yields light-induced changes in behavior. The activity of PACs is strongly and reversibly enhanced by blue light, providing a powerful tool for light-induced manipulation of cAMP in animal cells.

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Language(s): eng - English
 Dates: 2006-05-312006-10-122006-11-262007-01-01
 Publication Status: Issued
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/nmeth975
PMID: 17128267
 Degree: -

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Title: Nature Methods
  Other : Nature Methods
Source Genre: Journal
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Publ. Info: New York, NY : Nature Pub. Group
Pages: - Volume / Issue: 4 (1) Sequence Number: - Start / End Page: 39 - 42 Identifier: ISSN: 1548-7091
CoNE: https://pure.mpg.de/cone/journals/resource/111088195279556