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  Transporter Assays Using Solid Supported Membranes: A Novel Screening Platform for Drug Discovery

Kelety, B., Diekert, K., Tobien, J., Watzke, N., Dörner, W., Obrdlik, P., et al. (2006). Transporter Assays Using Solid Supported Membranes: A Novel Screening Platform for Drug Discovery. Assay and Drug Development Technologies, 4(5), 575-582. doi:10.1089/adt.2006.4.575.

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 Creators:
Kelety, Bela, Author
Diekert, Kerstin, Author
Tobien, Joanna, Author
Watzke, Natalie1, Author           
Dörner, Wolfgang, Author
Obrdlik, Petr, Author
Fendler, Klaus1, Author           
Affiliations:
1Department of Biophysical Chemistry, Max Planck Institute of Biophysics, Max Planck Society, ou_2068289              

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 Abstract: Transporters are important targets in drug discovery. However, high throughput-capable assays for this class of membrane proteins are still missing. Here we present a novel drug discovery platform technology based on solid supported membranes. The functional principles of the technology are described, and a sample selection of transporter assays is discussed: the H(+)-dependent peptide transporter PepT1, the gastric proton pump, and the Na(+)/Ca(2+) exchanger. This technology promises to have an important impact on the drug discovery process.

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Language(s): eng - English
 Dates: 2006
 Publication Status: Published in print
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 301842
DOI: 10.1089/adt.2006.4.575
 Degree: -

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Title: Assay and Drug Development Technologies
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Mary Ann Liebert
Pages: - Volume / Issue: 4 (5) Sequence Number: - Start / End Page: 575 - 582 Identifier: ISSN: 1540-658X