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  Millisecond-timescale, genetically targeted optical control of neural activity

Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G., & Deisseroth, K. (2005). Millisecond-timescale, genetically targeted optical control of neural activity. Nature Neuroscience, 8(9), 1263-1268. doi:10.1038/nn1525.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-D9F6-F Version Permalink: https://hdl.handle.net/21.11116/0000-000A-6CD2-0
Genre: Journal Article

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 Creators:
Boyden, Edward S.1, Author
Zhang, Feng1, Author
Bamberg, Ernst2, 3, Author           
Nagel, Georg2, 4, Author           
Deisseroth, Karl1, 5, Author
Affiliations:
1Department of Bioengineering, Stanford University, 318 Campus Drive West, Stanford, 94305, California, USA, ou_persistent22              
2Department of Biophysical Chemistry, Max Planck Institute of Biophysics, Max Planck Society, ou_2068289              
3Department of Biochemistry, Chemistry and Pharmaceutics, University of Frankfurt, 60439 Frankfurt am Main, Germany, ou_persistent22              
4Julius-von-Sachs-Institut, Universität Würzburg, 97082 Würzburg, Germany, ou_persistent22              
5Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, 401 Quarry Road, Stanford, 94305, California, USA, ou_persistent22              

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 Abstract: Temporally precise, noninvasive control of activity in well-defined neuronal populations is a long-sought goal of systems neuroscience. We adapted for this purpose the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, by using lentiviral gene delivery in combination with high-speed optical switching to photostimulate mammalian neurons. We demonstrate reliable, millisecond-timescale control of neuronal spiking, as well as control of excitatory and inhibitory synaptic transmission. This technology allows the use of light to alter neural processing at the level of single spikes and synaptic events, yielding a widely applicable tool for neuroscientists and biomedical engineers

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Language(s): eng - English
 Dates: 2005-05-122005-07-262005-08-142005-09-08
 Publication Status: Issued
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/nn1525
PMID: 16116447
 Degree: -

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Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
 Creator(s):
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 8 (9) Sequence Number: - Start / End Page: 1263 - 1268 Identifier: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931