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  Channelrhodopsin-1: A light-gated proton channel in green algae

Nagel, G., Ollig, D., Fuhrmann, M., Kateriya, S., Mustl, A. M., Bamberg, E., et al. (2002). Channelrhodopsin-1: A light-gated proton channel in green algae. Science, 296(5577), 2395-2398. doi:10.1126/science.1072068.

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 Creators:
Nagel, Georg1, Author              
Ollig, Doris1, Author              
Fuhrmann, Markus2, Author
Kateriya, Suneel2, Author
Mustl, Anna Maria3, Author
Bamberg, Ernst1, Author              
Hegemann, Peter2, Author
Affiliations:
1Department of Biophysical Chemistry, Max Planck Institute of Biophysics, Max Planck Society, ou_2068289              
2Institut für Biochemie, Universität Regensburg, Universitätsstrasse 31, 93040 Regensburg, Germany, ou_persistent22              
3Dipartimento Farmaco-Biologico Università della Calabria, 87036 Rende, Italy, ou_persistent22              

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Free keywords: voltage-dependence; bacteriorhodopsin; chlamydomonas; ; rhodopsin; photoreceptor; phototaxis; resolution; protein
 Abstract: Phototaxis and photophobic responses of green algae are mediated by rhodopsins with microbial-type chromophores. We report a complementary DNA sequence in the green alga Chlamydomonas reinhardtii that encodes a microbial opsin- related protein, which we term Channelopsin-1. The hydrophobic core region of the protein shows homology to the light- activated proton pump bacteriorhodopsin. Expression of Channelopsin-1, or only the hydrophobic core, in Xenopus laevis oocytes in the presence of all-trans retinal produces a light- gated conductance that shows characteristics of a channel selectively permeable for protons. We suggest that Channelrhodopsins are involved in phototaxis of green algae.

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Language(s): eng - English
 Dates: 2002-03-202002-05-222002-06-28
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1126/science.1072068
PMID: 12089443
 Degree: -

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Title: Science
  Abbreviation : Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 296 (5577) Sequence Number: - Start / End Page: 2395 - 2398 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1