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  Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase

Benjdia, A., Heil, K., Winkler, A., Carell, T., & Schlichting, I. (2014). Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase. Chemical Communications, 50(91), 14201-14204. doi:10.1039/C4CC05158K.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-947D-E Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-94B2-1
Genre: Journal Article

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 Creators:
Benjdia, Alhosna1, Author           
Heil, Korbinian, Author
Winkler, Andreas1, Author           
Carell, Thomas, Author
Schlichting, Ilme1, Author           
Affiliations:
1Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              

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 Abstract: The radical SAM enzyme, spore photoproduct lyase, requires an H-atom transfer (HAT) pathway to catalyze DNA repair. By rational engineering, we demonstrate that it is possible to rewire its HAT pathway, a first step toward the development of novel catalysts based on the radical SAM enzyme scaffold.

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Language(s): eng - English
 Dates: 2014-07-042014-09-182014-09-192014-11-25
 Publication Status: Issued
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1039/C4CC05158K
Other: 8044
URI: http://www.ncbi.nlm.nih.gov/pubmed/25285338
URI: http://pubs.rsc.org/en/content/articlehtml/2014/cc/c4cc05158k
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Title: Chemical Communications
  Other : Chem. Commun.
Source Genre: Journal
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Publ. Info: Cambridge, UK : Royal Society of Chemistry
Pages: - Volume / Issue: 50 (91) Sequence Number: - Start / End Page: 14201 - 14204 Identifier: ISSN: 1359-7345
CoNE: https://pure.mpg.de/cone/journals/resource/954928495413