非表示:
キーワード:
asymmetric synthesis; domino reactions;
Michael addition; organocatalysis; squaramide
要旨:
An expedient asymmetric synthesis of
polyfunctionalized indanols bearing four contiguous
stereogenic centres, including a quarternary centre
through the use of sub-mol% amounts of a squaramide
catalyst within minutes is presented. A gramscale
experiment of this Michael/Henry organcascade
pushes the frontier of catalyst loading of organocascades
down to only 0.1 mol%, attaining
a TON of up to 910.
