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  DNA-protein crosslink repair: proteases as DNA repair enzymes

Stingele, J., Habermann, B., & Jentsch, S. (2015). DNA-protein crosslink repair: proteases as DNA repair enzymes. Trends in biochemical sciences, 40(2), 67-71. doi:10.1016/j.tibs.2014.10.012.

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 Creators:
Stingele, Julian1, Author              
Habermann, Bianca2, Author              
Jentsch, Stefan1, Author              
Affiliations:
1Jentsch, Stefan / Molecular Cell Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565156              
2Habermann, Bianca / Computational Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1832284              

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 Abstract: DNA protein crosslinks (DPCs) are highly toxic DNA lesions because they interfere with DNA transactions. The recent discovery of a yeast protease that processes DPCs proteolytically raises the question whether DPC proteases also exist in higher eukaryotes. We argue here that the yeast enzyme, Wss1 (weak suppressor of smt3), is a member of a protease family whose mammalian representative is Spartan (SprT-like domain-containing protein)/DVC1 (DNA damage protein targeting VCP). DPC proteases may thus be common to all eukaryotes where they function as novel guardians of the genome.

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Language(s): eng - English
 Dates: 2015
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Trends in biochemical sciences
Source Genre: Journal
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Publ. Info: Elsevier Current Trends
Pages: - Volume / Issue: 40 (2) Sequence Number: - Start / End Page: 67 - 71 Identifier: ISSN: 0968-0004
CoNE: https://pure.mpg.de/cone/journals/resource/110975506070359