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  Threshold limits for biological indication of prolonged radiation exposure using mFISH

Osovets, S. V., Sotnik, N. V., Meineke, V., Scherthan, H., Dorr, H., & Azizova, T. V. (2014). Threshold limits for biological indication of prolonged radiation exposure using mFISH. Health Physics, 106(6), 677-681. doi:10.1097/HP.0000000000000057.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-C1AA-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-C1B0-9
Genre: Journal Article

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 Creators:
Osovets, S. V., Author
Sotnik, N. V., Author
Meineke, V., Author
Scherthan, H.1, Author              
Dorr, H., Author
Azizova, T. V., Author
Affiliations:
1Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              

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Free keywords: Aged Chromosome Aberrations/*radiation effects Female Humans *In Situ Hybridization, Fluorescence Male *Nuclear Power Plants Probability *Radioactive Hazard Release *Threshold Limit Values Time Factors
 Abstract: Chromosome aberration (translocation) yield was investigated by mFISH in peripheral blood lymphocytes of Mayak Production Association (PA) workers with prolonged occupational exposure to ionizing radiation (IR). A dose threshold for cytogenetic indication of a prolonged occupational radiation exposure was estimated for Mayak PA workers using functions of dose distributions. Two limits were estimated for the indication of IR exposure to workers with a prolonged external gamma-ray exposure: These are a background translocation yield of N(0) = 0.812 +/- 0.149% and a dose threshold of indication D(0) estimated to be approximately 1 Gy.

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Language(s): eng - English
 Dates: 2014-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1097/HP.0000000000000057
ISSN: 1538-5159 (Electronic)0017-9078 (Print)
 Degree: -

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Title: Health Physics
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: The Health Physics Society
Pages: - Volume / Issue: 106 (6) Sequence Number: - Start / End Page: 677 - 681 Identifier: -