Coiled-Coils in Phage Display Screening: Insight into Exceptional Selectivity 
Provided by Molecular Dynamics

Mortier, Jeremie; Nyakatura, Elisabeth K.; Reimann, Oliver; Huhmann, Susanne; Daldrop, Jan O.; Baldauf, Carsten; Wolber, Gerhard; Miettinen, Markus S.; Koksch, Beate

doi:10.1021/ci500689c

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Coiled-Coils in Phage Display Screening: Insight into Exceptional Selectivity Provided by Molecular Dynamics

Mortier, J., Nyakatura, E. K., Reimann, O., Huhmann, S., Daldrop, J. O., Baldauf, C., et al. (2015). Coiled-Coils in Phage Display Screening: Insight into Exceptional Selectivity Provided by Molecular Dynamics. Journal of Chemical Information and Modeling, 55(3), 495-500. doi:10.1021/ci500689c.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0026-C2E2-F Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0026-C2E3-D

Genre: Journal Article

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Creators:
Mortier, Jeremie¹, Author
Nyakatura, Elisabeth K.¹, Author
Reimann, Oliver¹, Author
Huhmann, Susanne¹, Author
Daldrop, Jan O.², Author
Baldauf, Carsten³, Author
Wolber, Gerhard¹, Author
Miettinen, Markus S.², Author
Koksch, Beate¹, Author

Affiliations:
1Department of Biology, Chemistry and Pharmacy, Freie Universität Berlin, Takustraße 3, 14195 Berlin, Germany, ou_persistent22
2Department of Physics, Freie Universität Berlin, Arnimallee 14, 14195 Berlin, Germany, ou_persistent22
3Theory, Fritz Haber Institute, Max Planck Society, ou_634547

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Abstract: Involved in numerous key biological functions, protein helix–helix interactions follow a well-defined intermolecular recognition pattern. The characteristic structure of the α-helical coiled-coil allows for the specific randomization of clearly defined interaction partners within heteromeric systems. In this work, a rationally designed heterodimeric coiled-coil was used to investigate potential factors influencing the sequence selectivity in interhelical interactions.

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Language(s): eng - English

Dates: Accepted: 2015-02-03Published Online: 2015-02-03Date issued: 2015-03-23

Publication Status: Issued

Pages: 6

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Rev. Type: Peer

Identifiers: DOI: 10.1021/ci500689c

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Title: Journal of Chemical Information and Modeling

Source Genre: Journal

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Publ. Info: Washington, D.C. : American Chemical Society

Pages: - Volume / Issue: 55 (3) Sequence Number: - Start / End Page: 495 - 500 Identifier: ISSN: 1549-9596
CoNE: https://pure.mpg.de/cone/journals/resource/954925465222