Coiled-Coils in Phage Display Screening: Insight into Exceptional Selectivity 
Provided by Molecular Dynamics

Mortier, Jeremie; Nyakatura, Elisabeth K.; Reimann, Oliver; Huhmann, Susanne; Daldrop, Jan O.; Baldauf, Carsten; Wolber, Gerhard; Miettinen, Markus S.; Koksch, Beate

doi:10.1021/ci500689c

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Coiled-Coils in Phage Display Screening: Insight into Exceptional Selectivity Provided by Molecular Dynamics

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Baldauf, Carsten
Theory, Fritz Haber Institute, Max Planck Society;

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Citation

Mortier, J., Nyakatura, E. K., Reimann, O., Huhmann, S., Daldrop, J. O., Baldauf, C., et al. (2015). Coiled-Coils in Phage Display Screening: Insight into Exceptional Selectivity Provided by Molecular Dynamics. Journal of Chemical Information and Modeling, 55(3), 495-500. doi:10.1021/ci500689c.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0026-C2E2-F

Abstract

Involved in numerous key biological functions, protein helix–helix interactions follow a well-defined intermolecular recognition pattern. The characteristic structure of the α-helical coiled-coil allows for the specific randomization of clearly defined interaction partners within heteromeric systems. In this work, a rationally designed heterodimeric coiled-coil was used to investigate potential factors influencing the sequence selectivity in interhelical interactions.