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  Functional MRI in human subjects with gradient-echo and spin-echo EPI at 9.4 T

Budde, J., Shajan, G., Zaitsev, M., Scheffler, K., & Pohmann, R. (2014). Functional MRI in human subjects with gradient-echo and spin-echo EPI at 9.4 T. Magnetic Resonance in Medicine, 71(1), 209-218. doi:10.1002/mrm.24656.

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Budde, J1, 2, Author              
Shajan, G1, 2, Author              
Zaitsev, M, Author
Scheffler, K1, 2, Author              
Pohmann, R1, 2, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: PURPOSE: The increased signal-to-noise ratio and blood oxygen level dependent signal at ultra-high field can only help to boost the resolution in functional MRI studies if the spatial specificity of the activation signal is improved. At a field strength of 9.4 T, both gradient-echo and spin-echo based echo-planar imaging were implemented and applied to investigate the specificity of human functional MRI. A finger tapping paradigm was used to acquire functional MRI data with scan parameters similar to standard neuroscientific applications. METHODS: Spatial resolution, echo, and readout times were varied to determine their influence on the distribution of the blood oxygen level dependent signal. High-resolution co-localized images were used to classify the signal according to its origin in veins or tissue. RESULTS: High-quality activation maps were obtained with both sequences. Signal contributions from tissue were found to be smaller or slightly larger than from veins. Gradient-echo echo-planar imaging yielded lower ratios of micro-/macro-vascular signals of around 0.6 than spin-echo based functional MRI, where this ratio varied between 0.75 and 1.02, with higher values for larger echo and shorter readout time. CONCLUSION: This study demonstrates the feasibility of human functional MRI at 9.4 T with high spatial specificity. Although venous contributions could not be entirely suppressed, venous effects in spin-echo echo-planar imaging are significantly reduced compared with gradient-echo echo-planar imaging.

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 Dates: 2013-022014-01
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/mrm.24656
BibTex Citekey: BuddeSZSP2013
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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 71 (1) Sequence Number: - Start / End Page: 209 - 218 Identifier: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149