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  Amphipathic DNA Origami Nanoparticles to Scaffold and Deform Lipid Membrane Vesicles

Czogalla, A., Kauert, D. J., Franquelim, H. G., Uzunova, V., Zhang, Y., Seidel, R., et al. (2015). Amphipathic DNA Origami Nanoparticles to Scaffold and Deform Lipid Membrane Vesicles. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 54(22), 6501-6505. doi:10.1002/anie.201501173.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-A723-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-A724-4
Genre: Journal Article

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 Creators:
Czogalla, Aleksander1, Author
Kauert, Dominik J.1, Author
Franquelim, Henri G.2, Author              
Uzunova, Veselina1, Author
Zhang, Yixin1, Author
Seidel, Ralf1, Author
Schwille, Petra2, Author              
Affiliations:
1external, ou_persistent22              
2Schwille, Petra / Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565169              

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Free keywords: NANOSCALE SHAPES; BAR DOMAINS; FOLDING DNA; PROTEIN; NANOSTRUCTURES; MECHANISMS; CURVATURE; VIRUSdiffusion; lipid membranes; membrane deformation; oligomerization; origami DNA structures;
 Abstract: We report a synthetic biology-inspired approach for the engineering of amphipathic DNA origami structures as membrane-scaffolding tools. The structures have a flat membrane-binding interface decorated with cholesterol-derived anchors. Sticky oligonucleotide overhangs on their side facets enable lateral interactions leading to the formation of ordered arrays on the membrane. Such a tight and regular arrangement makes our DNA origami capable of deforming free-standing lipid membranes, mimicking the biological activity of coat-forming proteins, for example, from the I-/F-BAR family.

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Language(s): eng - English
 Dates: 2015
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: ISI: 000355229800016
DOI: 10.1002/anie.201501173
 Degree: -

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Title: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Source Genre: Journal
 Creator(s):
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Publ. Info: BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY : WILEY-V C H VERLAG GMBH
Pages: - Volume / Issue: 54 (22) Sequence Number: - Start / End Page: 6501 - 6505 Identifier: ISSN: 1433-7851