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  Validation of tractography: Comparison with manganese tracing

Knösche, T. R., Anwander, A., Liptrop, M., & Dyrby, T. (2015). Validation of tractography: Comparison with manganese tracing. Human Brain Mapping, 36(10), 4116-4134. doi:10.1002/hbm.22902.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-D584-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-765F-F
Genre: Journal Article

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Knoesche_HumBrainMapp_preprint_2015.pdf (Preprint), 5MB
 
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 Creators:
Knösche, Thomas R.1, Author              
Anwander, Alfred2, Author              
Liptrop, Matthew3, 4, Author
Dyrby, Tim3, Author
Affiliations:
1Methods and Development Group MEG and EEG - Cortical Networks and Cognitive Functions, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2205650              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
3Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Denmark, ou_persistent22              
4Department of Computer Science, University of Copenhagen, Denmark, ou_persistent22              

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Free keywords: MRI; Brain connections; DTI; Crossing fibers; White matter; Tracking
 Abstract: In this study, we used invasive tracing to evaluate white matter tractography methods based on ex vivo diffusion-weighted magnetic resonance imaging (dwMRI) data. A representative selection of tractography methods were compared to manganese tracing on a voxel-wise basis, and a more qualitative assessment examined whether, and to what extent, certain fiber tracts and gray matter targets were reached. While the voxel-wise agreement was very limited, qualitative assessment revealed that tractography is capable of finding the major fiber tracts, although there were some differences between the methods. However, false positive connections were very common and, in particular, we discovered that it is not possible to achieve high sensitivity (i.e., few false negatives) and high specificity (i.e., few false positives) at the same time. Closer inspection of the results led to the conclusion that these problems mainly originate from regions with complex fiber arrangements or high curvature and are not easily resolved by sophisticated local models alone. Instead, the crucial challenge in making tractography a truly useful and reliable tool in brain research and neurology lies in the acquisition of better data. In particular, the increase of spatial resolution, under preservation of the signal-to-noise-ratio, is key.

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Language(s): eng - English
 Dates: 2015-01-132015-07-012015-07-142015-10-01
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/hbm.22902
PMID: 26178765
PMC: PMC5034837
Other: Epub 2015
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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 36 (10) Sequence Number: - Start / End Page: 4116 - 4134 Identifier: ISSN: 1065-9471
CoNE: /journals/resource/954925601686