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  A shared vesicular carrier allows synaptic corelease of GABA and glycine

Wojcik, S. M., Katsurabayashi, S., Guillemin, I., Friauf, E., Rosenmund, C., Brose, N., et al. (2006). A shared vesicular carrier allows synaptic corelease of GABA and glycine. Neuron, 50(4), 575-587. doi:10.1016/j.neuron.2006.04.016.

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 Creators:
Wojcik, Sonja M.1, Author              
Katsurabayashi, Shutaro, Author
Guillemin, Isabelle, Author
Friauf, Eckhard, Author
Rosenmund, Christian, Author
Brose, Nils1, Author              
Rhee, Jeong-Seop2, Author              
Affiliations:
1Molecular neurobiology, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173659              
2Neurophysiology of synapse, Molecular neurobiology, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173660              

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Free keywords: GLUTAMIC-ACID DECARBOXYLASE; GAMMA-AMINOBUTYRIC-ACID; MOUSE HIPPOCAMPAL-NEURONS; AUDITORY BRAIN-STEM; DEVELOPMENTAL SWITCH; EXCITATORY ACTIONS; SPINAL NEURONS; CLEFT-PALATE; RAT; VESICLES
 Abstract: The type of vesicular transporter expressed by a neuron is thought to determine its neurotransmitter phenotype. We show that inactivation of the vesicular inhibitory amino acid transporter (Viaat, VGAT) leads to embryonic lethality, an abdominal defect known as omphalocele, and a cleft palate. Loss of Viaat causes a drastic reduction of neurotransmitter release in both GABAergic and glycinergic neurons, indicating that glycinergic neurons do not express a separate vesicular glycine transporter. This loss of GABAergic and glycinergic synaptic transmission does not impair the development of inhibitory synapses or the expression of KCC2, the K+-Cl- cotransporter known to be essential for the establishment of inhibitory neurotransmission. In the absence of Viaat, GABA-synthesizing enzymes are partially lost from presynaptic terminals. Since GABA and glycine compete for vesicular uptake, these data point to a close association of Viaat with GABA-synthesizing enzymes as a key factor in specifying GABAergic neuronal phenotypes.

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Language(s): eng - English
 Dates: 2006-05
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 292183
ISI: 000237875200009
ISI: 000237875200009
DOI: 10.1016/j.neuron.2006.04.016
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Title: Neuron
  Alternative Title : Neuron
Source Genre: Journal
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Pages: - Volume / Issue: 50 (4) Sequence Number: - Start / End Page: 575 - 587 Identifier: ISSN: 0896-6273