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  Cyclin-dependent kinase 5 is required for associative learning

Fischer, A., Sananbenesi, F., Schrick, C., Spiess, J., & Radulovic, J. (2002). Cyclin-dependent kinase 5 is required for associative learning. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 22(9), 3700-3707.

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Fischer, Andre1, Autor           
Sananbenesi, Farahnaz1, Autor           
Schrick, Christina1, Autor           
Spiess, Joachim1, Autor           
Radulovic, Jelena1, Autor           
Affiliations:
1Molecular neuroendocrinology, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173662              

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Schlagwörter: cyclin-dependent kinase 5; stress; fear conditioning; septum; hippocampus; cholinergic; mice
 Zusammenfassung: Transient stressful experiences may persistently facilitate associative and nonassociative learning, possibly through alterations of gene expression. Here we identify, by subtractive hybridization, differential expression of the Cdk5 gene in response to stress. The Cdk5 protein is selectively induced in the fibers of septohippocampal cholinergic neurons but not in other regions of prominent Cdk5 production. This upregulation is accompanied by increased Cdk5 kinase activity, which is blocked completely by the Cdk5 inhibitor butyrolactone I. Microinjection of butyrolactone I into the lateral septum and hippocampus prevents the acquisition of conditioned context-dependent fear as well as its stress-induced facilitation. By demonstrating that a transient increase of Cdk5 activity within the septohippocampal system is required for associative learning, an important novel role of Cdk5 has been identified.

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Sprache(n): eng - English
 Datum: 2002-05-01
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 18999
ISI: 000175296200047
 Art des Abschluß: -

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Titel: The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
  Andere : J. Neurosci.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Baltimore, MD : The Society
Seiten: - Band / Heft: 22 (9) Artikelnummer: - Start- / Endseite: 3700 - 3707 Identifikator: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1