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  Blood coagulation with domestic deep-seated mycoses

Ntefidou, M., Elsner, C., Spreer, A., Weinstock, N., Kratzin, H. D., & Rüchel, R. (2002). Blood coagulation with domestic deep-seated mycoses. Mycoses, 45(Suppl. 1), 53-56.

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 Creators:
Ntefidou, Maria, Author
Elsner, Christine, Author
Spreer, Annette, Author
Weinstock, N., Author
Kratzin, Hartmut D.1, Author           
Rüchel, R., Author
Affiliations:
1Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173664              

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Free keywords: Candidosis; Aspergillosis; Mucorales-mycosis; Blood coagulation; Fungal proteinase
 Abstract: Activation of blood coagulation to a varying extent affect the course of domestic invasive mycoses. Upon invasion of blood vessels by Candida or aspergilli, occasionally thrombi are formed, which may cause septic embolism. In the course of mucormycosis (syn. zygomycosis) thrombotic occlusion of afflicted blood vessels and subsequent necrosis of dependent tissue regularly occurs. Coagulation during candidosis or aspergillosis may be triggered by secreted aspartic proteinases which are able to activate factor X as has been shown previously [1, 2]. During mucormycosis, severe blood coagulation apparently is due to paracoagulation of fibrinogen which is triggered by low concentrations of extracellular fungal subtilisin-like proteinase (Arp). The enzyme is also able to inactivate the major inhibitor 4 blood coagulation (antithrombin III). Recent findings on the action of Arp are discussed.

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Language(s): eng - English
 Dates: 2002
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 711998
ISI: 000175485200010
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Title: Mycoses
Source Genre: Journal
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Publ. Info: Berlin : Grosse
Pages: - Volume / Issue: 45 (Suppl. 1) Sequence Number: - Start / End Page: 53 - 56 Identifier: ISSN: 0933-7407
CoNE: https://pure.mpg.de/cone/journals/resource/110978979782089