English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
 Local TagsRelease HistoryDetailsSummary
  Direct action of endocrine disrupting chemicals on human sperm

Schiffer, C., Müller, A., Egeberg, D. L., Alvarez, L., Brenker, C., Rehfeld, A., et al. (2014). Direct action of endocrine disrupting chemicals on human sperm. EMBO Reports, 15(7), 758-765. doi:10.15252/embr.201438869.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0028-6195-9 Version Permalink: https://hdl.handle.net/21.11116/0000-0005-C5EF-0
Genre: Journal Article

Files

show Files
hide Files
:
Schiffer_Direct.pdf (Any fulltext), 6MB
 
File Permalink:
-
Name:
Schiffer_Direct.pdf
Description:
-
OA-Status:
Visibility:
Private
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Locator:
https://www.embopress.org/doi/full/10.15252/embr.201438869 (Abstract)
Description:
+ full text
OA-Status:

Creators

show
hide
 Creators:
Schiffer, Christian1, Author           
Müller, Astrid1, Author           
Egeberg, Dorte L.2, Author
Alvarez, Luis1, Author           
Brenker, Christoph1, Author           
Rehfeld, Anders2, Author
Frederiksen, Hanne2, Author
Wäschle, Benjamin1, Author
Kaupp, Ulrich Benjamin1, Author           
Balbach, Melanie1, Author           
Wachten, Dagmar3, Author           
Skakkebaek, Nils E.2, Author
Almstrup, Kristian2, Author
Strünker, Timo1, Author           
Affiliations:
1Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society, Ludwig-Erhard-Allee 2, 53175 Bonn, DE, ou_2173679              
2External Organizations, ou_persistent22              
3Max Planck Research Group Molecular Physiology, Center of Advanced European Studies and Research (caesar), Max Planck Society, Ludwig-Erhard-Allee 2, 53175 Bonn, DE, ou_2173682              

Content

show
hide
Free keywords: Ca2+ signalling; CatSper; endocrine disrupting chemical; human sperm
 Abstract: Synthetic endocrine disrupting chemicals (EDCs), omnipresent in
food, household, and personal care products, have been implicated
in adverse trends in human reproduction, including infertility and
increasing demand for assisted reproduction. Here, we study the
action of 96 ubiquitous EDCs on human sperm. We show that
structurally diverse EDCs activate the sperm-specific CatSper
channel and, thereby, evoke an intracellular Ca2+ increase, a motility response, and acrosomal exocytosis. Moreover, EDCs desensitize sperm for physiological CatSper ligands and cooperate in
low-dose mixtures to elevate Ca2+ levels in sperm. We conclude
that EDCs interfere with various sperm functions and, thereby,
might impair human fertilization.

Details

show
hide
Language(s): eng - English
 Dates: 2014-05-122014-07
 Publication Status: Issued
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.15252/embr.201438869
PMID: 24820036
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: EMBO Reports
  Other : EMBO Rep
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Oxford, UK : Published for EMBO by Oxford University Press
Pages: - Volume / Issue: 15 (7) Sequence Number: - Start / End Page: 758 - 765 Identifier: ISSN: 1469-221X
CoNE: https://pure.mpg.de/cone/journals/resource/110978984569661