Direct action of endocrine disrupting chemicals on human sperm

Schiffer, Christian; Müller, Astrid; Egeberg, Dorte L.; Alvarez, Luis; Brenker, Christoph; Rehfeld, Anders; Frederiksen, Hanne; Wäschle, Benjamin; Kaupp, Ulrich Benjamin; Balbach, Melanie; Wachten, Dagmar; Skakkebaek, Nils E.; Almstrup, Kristian; Strünker, Timo

doi:10.15252/embr.201438869

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学術論文

Direct action of endocrine disrupting chemicals on human sperm

MPS-Authors

/persons/resource/persons182762

Schiffer, Christian
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

/persons/resource/persons182751

Müller, Astrid
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

/persons/resource/persons182717

Alvarez, Luis
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

/persons/resource/persons182722

Brenker, Christoph
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

Wäschle, Benjamin
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

/persons/resource/persons182743

Kaupp, Ulrich Benjamin
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

/persons/resource/persons182718

Balbach, Melanie
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

/persons/resource/persons182737

Wachten, Dagmar
Max Planck Research Group Molecular Physiology, Center of Advanced European Studies and Research (caesar), Max Planck Society;

/persons/resource/persons182770

Strünker, Timo
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

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https://www.embopress.org/doi/full/10.15252/embr.201438869
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引用

Schiffer, C., Müller, A., Egeberg, D. L., Alvarez, L., Brenker, C., Rehfeld, A., Frederiksen, H., Wäschle, B., Kaupp, U. B., Balbach, M., Wachten, D., Skakkebaek, N. E., Almstrup, K., & Strünker, T. (2014). Direct action of endocrine disrupting chemicals on human sperm. EMBO Reports, 15(7), 758-765. doi:10.15252/embr.201438869.

引用: https://hdl.handle.net/11858/00-001M-0000-0028-6195-9

要旨

Synthetic endocrine disrupting chemicals (EDCs), omnipresent in
food, household, and personal care products, have been implicated
in adverse trends in human reproduction, including infertility and
increasing demand for assisted reproduction. Here, we study the
action of 96 ubiquitous EDCs on human sperm. We show that
structurally diverse EDCs activate the sperm-specific CatSper
channel and, thereby, evoke an intracellular Ca2+ increase, a motility response, and acrosomal exocytosis. Moreover, EDCs desensitize sperm for physiological CatSper ligands and cooperate in
low-dose mixtures to elevate Ca2+ levels in sperm. We conclude
that EDCs interfere with various sperm functions and, thereby,
might impair human fertilization.