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  Conditional restoration of hippocampal synaptic potentiation in GluR-A-deficient mice

Mack, V., Burnashev, N., Kaiser, K., Rozov, A., Jensen, V., Hvalby, Ø., et al. (2001). Conditional restoration of hippocampal synaptic potentiation in GluR-A-deficient mice. Science, 292(5526), 2501-2504. doi:10.1126/science.1059365.

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Genre: Journal Article
Alternative Title : Conditional restoration of hippocampal synaptic potentiation in GluR-A-deficient mice

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Science_292_2001_2501.pdf (Any fulltext), 441KB
 
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Mack, Volker1, Author              
Burnashev, Nail2, Author              
Kaiser, Katharina2, Author              
Rozov, Andrej1, 2, Author              
Jensen, Vidar, Author
Hvalby, Øivind, Author
Seeburg, Peter H.1, Author              
Sakmann, Bert2, Author              
Sprengel, Rolf1, Author              
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1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: Plasticity of mature hippocampal CA1 synapses is dependent on l-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit. In GluR-A-deficient mice, plasticity could be restored by controlled expression of green fluorescent protein (GFP)-tagged GluR-A, which contributes to channel formation and displayed the developmental redistribution of AMPA receptors in CA1 pyramidal neurons. Long-term potentiation (LTP) induced by pairing or tetanic stimulation was rescued in adult GluR-A(-/-) mice when (GFP)GluR-A expression was constitutive or induced in already fully developed pyramidal cells. This shows that GluR-A-independent forms of synaptic plasticity can mediate the establishment of mature hippocampal circuits that are prebuilt to express GluR-A-dependent LTP.

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Language(s): eng - English
 Dates: 2001-01-292001-05-162001-06-29
 Publication Status: Published in print
 Pages: 4
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 Table of Contents: -
 Rev. Type: Peer
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Title: Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 292 (5526) Sequence Number: - Start / End Page: 2501 - 2504 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1