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  A common building block for the syntheses of amorfrutin and cajaninstilbene acid libraries toward efficient binding with peroxisome proliferator-activated receptors

Aidhen, I. S., Mukkamala, R., Weidner, C., & Sauer, S. (2015). A common building block for the syntheses of amorfrutin and cajaninstilbene acid libraries toward efficient binding with peroxisome proliferator-activated receptors. Organic Letters, 17(2), 194-197. doi:10.1021/ol503135u.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-55EF-5 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-55F0-0
Genre: Journal Article

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© 2014 American Chemical Society
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Aidhen, I. S., Author
Mukkamala, R., Author
Weidner, C.1, Author           
Sauer, S.1, Author           
Affiliations:
1Nutrigenomics and Gene Regulation (Sascha Sauer), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479662              

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Free keywords: Hypoglycemic Agents/*chemical synthesis/chemistry Ligands Molecular Structure Peroxisome Proliferator-Activated Receptors/*chemistry/metabolism Salicylates/*chemical synthesis/chemistry Stilbenes/*chemical synthesis/chemistry
 Abstract: A common building block for the synthesis of amorfrutin and cajaninstilbene acid derivatives has been developed. The library of synthesized compounds has enabled identification of new nontoxic ligands of peroxisome proliferator-activated receptors (PPAR) and potential inhibitors of the transcriptional corepressor protein NCoR. The biological data holds promise in identification of new potential leads for the antidiabetic drug discovery process.

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Language(s): eng - English
 Dates: 2014-12-232015-01-16
 Publication Status: Issued
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1021/ol503135u
ISSN: 1523-7052 (Electronic)
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Title: Organic Letters
  Other : Org. Lett.
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 17 (2) Sequence Number: - Start / End Page: 194 - 197 Identifier: ISSN: 1523-7060
CoNE: https://pure.mpg.de/cone/journals/resource/954925626338