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  Coherence-gated wave-front sensing in strongly scattering samples

Feierabend, M. (2004). Coherence-gated wave-front sensing in strongly scattering samples. PhD Thesis, Ruprecht-Karls-Universität Heidelberg, Heidelberg.

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Alternative Title : Coherence-gated wave-front sensing in strongly scattering samples

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Feierabend_Diss_2004.pdf (Any fulltext), 3MB
 
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Feierabend, Marcus1, Author           
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1Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              

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Free keywords: Adaptive Optik, Wellenfront, Wellenfrontsensor, Optische Kohärenz, Fluoreszenzmikroskopie ; Optische Kohärenztomographie , Adaptive Optics , Wave-Front Sensing , Coherence , Optical Coherence Tomography , Fluorescence Microscopy
 Abstract: In this thesis coherence-gated wave-front sensing (CGWS), a new approach for measuring wave-fronts in strongly scattering samples, is presented. This method combines Shack-Hartmann wave-front sensing and phase shifting interferometry (PSI). It employs virtual lenses to mimic the function of a conventional Shack-Hartmann sensor. The use of a modal estimation algorithm allows an approximation of the measured wave-front with a linear combination of Zernike polynomials up to the fifth radial degree. The principle of CGWS is tested by measuring two wave-front aberrations, defocus and astigmatism, for a mirror as a sample and a strongly scattering sample. The results are compared to theoretical models. The main advantage of CGWS is the discrimination against light backscattered from outside the focal region. A further advantage is the increase in the effective detection sensitivity. The capabilities of CGWS are demonstrated with wave-front measurements in scattering samples in the presence of background light that is dominant by about three orders of magnitude. In various microscopy applications, the ability to pre-emptively correct the wave-front, employing CGWS measurement data, may allow improvements of the optical focus and thus enhance the resolution and depth penetration in tissue considerably.

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Language(s): eng - English
 Dates: 20042004
 Publication Status: Issued
 Pages: 98
 Publishing info: Heidelberg : Ruprecht-Karls-Universität Heidelberg
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 665783
Other: 6172
URI: http://archiv.ub.uni-heidelberg.de/volltextserver/4836/
 Degree: PhD

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