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  Improved liposomes-based Ca(II) responsive MRI contrast agents

Garello, F., Vibhute, S., Gündüz, S., Logothetis, N., Angelovski, G., & Terreno, E. (2015). Improved liposomes-based Ca(II) responsive MRI contrast agents. Poster presented at 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015), Toronto, Canada.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-45E9-7 Version Permalink: https://hdl.handle.net/21.11116/0000-0006-9B84-6
Genre: Poster

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http://www.ismrm.org/15/program_files/WedTP01.htm (Publisher version)
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 Creators:
Garello, F, Author
Vibhute, S1, 2, Author           
Gündüz, S2, 3, Author           
Logothetis, NK1, 2, Author           
Angelovski, G2, 3, Author           
Terreno, E, Author
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528691              
3Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: This contribution reports a methodology that enables the preparation of paramagnetic liposomes loaded with an amphiphilic ligand capable to coordinate selectively and sequentially Gd(III) and Ca(II) ions, respectively. The presence of Gd(III) imparts the ability to generate MRI contrast, which is remarkably boosted (ca. 400) by the coordination of Ca(II), thus improving the calcium responsiveness of the nanoprobes with respect similar agents previously investigated.

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 Dates: 2015-06
 Publication Status: Issued
 Pages: -
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 Identifiers: BibTex Citekey: GarelloVGLAT2015
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Title: 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015)
Place of Event: Toronto, Canada
Start-/End Date: 2015-05-30 - 2015-06-05

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Title: 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 1899 Start / End Page: - Identifier: -