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  Human cerebellar sub-millimeter diffusion imaging reveals the motor and non-motor topography of the dentate nucleus

Steele, C., Anwander, A., Bazin, P.-L., Trampel, R., Schäfer, A., Turner, R., et al. (2017). Human cerebellar sub-millimeter diffusion imaging reveals the motor and non-motor topography of the dentate nucleus. Cerebral Cortex, 27(9), 4537-4548. doi:10.1093/cercor/bhw258.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-4958-B Version Permalink: http://hdl.handle.net/21.11116/0000-0003-C879-4
Genre: Journal Article

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 Creators:
Steele, Christopher1, Author              
Anwander, Alfred2, Author              
Bazin, Pierre-Louis1, 3, Author              
Trampel, Robert3, Author              
Schäfer, Andreas3, Author              
Turner, Robert4, Author              
Ramnani, Narender5, Author
Villringer, Arno1, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
3Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2205649              
4Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634550              
5Department of Psychology, Royal Holloway University of London, United Kingdom, ou_persistent22              

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Free keywords: Cerebellum and cognition; Cortico-cerebellar loop; Dentate nucleus; Motor and non-motor cerebellar white-matter connectivity
 Abstract: The reciprocal cortico-cerebellar loops that underlie cerebellar contributions to motor and cognitive behavior form one of the largest systems in the primate brain. Work with non-human primates has shown that the dentate nucleus, the major output nucleus of the cerebellum, contains topographically distinct connections to both motor and non-motor regions, yet there is no evidence for how the cerebellar cortex connects to the dentate nuclei in humans. Here we used in-vivo sub-millimeter diffusion imaging to characterize this fundamental component of the cortico-cerebellar loop, and identified a pattern of superior motor and infero-lateral non-motor connectivity strikingly similar to that proposed by animal work. Crucially, we also present first evidence that the dominance for motor connectivity observed in non-human primates may be significantly reduced in man – a finding that is in accordance with the proposed increase in cerebellar contributions to higher cognitive behavior over the course of primate evolution.

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Language(s): eng - English
 Dates: 2016-07-272016-08-012016-09-062017-09-01
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1093/cercor/bhw258
PMID: 27600851
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Funding program : Post-Doctoral Fellowship
Funding organization : Fonds de recherche du Québec – Nature et technologies (FRQNT)

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Title: Cerebral Cortex
Source Genre: Journal
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Pages: - Volume / Issue: 27 (9) Sequence Number: - Start / End Page: 4537 - 4548 Identifier: ISSN: 1047-3211
CoNE: /journals/resource/954925592440