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  Combined PET/MRI: Multimodality insights into acute stroke hemodynamics

Werner, P., Saur, D., Mildner, T., Möller, H. E., Classen, J., Sabri, O., et al. (2016). Combined PET/MRI: Multimodality insights into acute stroke hemodynamics. Neurology, 86(20), 1926-1927. doi:10.1212/WNL.0000000000002682.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-1782-F Version Permalink: http://hdl.handle.net/21.11116/0000-0003-19BB-F
Genre: Journal Article

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 Creators:
Werner, Peter1, Author
Saur, Dorothee1, Author
Mildner, Toralf2, Author              
Möller, Harald E.2, Author              
Classen, Joseph1, Author
Sabri, Osama1, Author
Hoffmann, Karl-Titus1, Author
Barthel, Henryk1, Author
Affiliations:
1University Hospital Leipzig, Germany, ou_persistent22              
2Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              

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 Abstract: A 61-year-old man underwent simultaneous PET/MRI 5.5 hours after sudden onset of aphasia (NIH Stroke Scale 4), which revealed a diffusion/perfusion mismatch of different extents as measured with pulsed arterial spin-labeling MRI (59 mL), perfusion-weighted MRI (27 mL), and [15O]H2O-PET (36 mL) (figure). Due to spontaneous recanalization, the penumbra tissue did not progress towards infarction. This demonstrates that the outcome of critically hypoperfused stroke brain tissue may be favorable even without sufficient collateral flow and without therapeutic intervention.1 Here, PET/MRI offers the chance to cross-evaluate MRI-based blood flow estimates against simultaneous PET in acute stroke, which may improve the understanding of stroke pathophysiology.

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Language(s): eng - English
 Dates: 2016-05-17
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1212/WNL.0000000000002682
PMID: 27185897
 Degree: -

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Title: Neurology
Source Genre: Journal
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Pages: - Volume / Issue: 86 (20) Sequence Number: - Start / End Page: 1926 - 1927 Identifier: ISSN: 0028-3878
CoNE: /journals/resource/954925246073