Production of a recombinant bacterial lipoprotein in higher plant chloroplasts

Glenz, Karin; Bouchon, Bernadette; Stehle, Thomas; Wallich, Reinhard; Simon, Markus M.; Warzecha, Heribert

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Production of a recombinant bacterial lipoprotein in higher plant chloroplasts

Glenz, K., Bouchon, B., Stehle, T., Wallich, R., Simon, M. M., & Warzecha, H. (2006). Production of a recombinant bacterial lipoprotein in higher plant chloroplasts. Nature Biotechnology, 24, 76-77.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-926C-5 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-926D-3

Genre: Journal Article

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Creators:
Glenz, Karin, Author
Bouchon, Bernadette, Author
Stehle, Thomas¹, Author
Wallich, Reinhard, Author
Simon, Markus M.¹, Author
Warzecha, Heribert, Author

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1Metchnikoff Laboratory, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243654

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Abstract: Little is known about the potential of plastids to accomplish post-translational modifications of foreign proteins. In the present study we generated transplastomic tobacco plants that accumulate the outer surface lipoprotein A (OspA)-the basic constituent of the first generation monovalent human vaccine against Lyme disease. The recombinant OspA exhibits a lipid modification typical for bacteria and induced protective antibodies in mice, demonstrating that functionally active bacterial lipoproteins can be processed in plants.

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Language(s): eng - English

Dates: Date issued: 2006-01

Publication Status: Issued

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Rev. Type: Peer

Identifiers: eDoc: 293378

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Title: Nature Biotechnology

Source Genre: Journal

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Pages: - Volume / Issue: 24 Sequence Number: - Start / End Page: 76 - 77 Identifier: -