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  Calcium permeability of ligand-gated channels

Burnashev, N. (1998). Calcium permeability of ligand-gated channels. Cell Calcium, 24(5), 325-332. doi:10.1016/S0143-4160(98)90056-2.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-962D-2 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-962F-D
Genre: Journal Article
Alternative Title : Calcium permeability of ligand-gated channels

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CellCalc_24_1998_325.pdf (Any fulltext), 2MB
 
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Burnashev, Nail1, Author           
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: Ligand-gated channels activated by excitatory neurotransmitters: glutamate, acetylcholine, ATP or serotonin are cation channels permeable to Ca2+. Molecular cloning revealed a large variety of the ligand-gated channel subunits differentially expressed in mammalian brain. Many of them have different Ca2+ permeability providing immense diversity in Ca2+ entry mediated by ligand-gated channels during synaptic transmission. Functional analysis of cloned channels allowed to identify structural elements in the pore forming regions determining Ca2+ permeability for many types of ligand-gated channels. The functional role of the Ca2+ entry mediated by various ligand-gated channels in mammalian central nervous system is less understood. The studies reviewed in this article provide information about known structural determinants of Ca2+ permeability of the ligand-gated channels and the role of this particular pathway of Ca2+ entry in cell function.

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Language(s): eng - English
 Dates: 1998-08-301998-09-212004-04-221998-11-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 666669
DOI: 10.1016/S0143-4160(98)90056-2
URI: https://www.ncbi.nlm.nih.gov/pubmed/10091002
URI: http://www.sciencedirect.com/science/article/pii/S0143416098900562
Other: 4252
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Title: Cell Calcium
Source Genre: Journal
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Publ. Info: Amsterdam, Netherlands : Churchill Livingstone
Pages: - Volume / Issue: 24 (5) Sequence Number: - Start / End Page: 325 - 332 Identifier: ISSN: 0143-4160
CoNE: https://pure.mpg.de/cone/journals/resource/954922647086