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  Calcium permeability of ligand-gated channels

Burnashev, N. (1998). Calcium permeability of ligand-gated channels. Cell Calcium, 24(5), 325-332. doi:10.1016/S0143-4160(98)90056-2.

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Alternativer Titel : Calcium permeability of ligand-gated channels

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CellCalc_24_1998_325.pdf (beliebiger Volltext), 2MB
 
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 Urheber:
Burnashev, Nail1, Autor           
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1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Zusammenfassung: Ligand-gated channels activated by excitatory neurotransmitters: glutamate, acetylcholine, ATP or serotonin are cation channels permeable to Ca2+. Molecular cloning revealed a large variety of the ligand-gated channel subunits differentially expressed in mammalian brain. Many of them have different Ca2+ permeability providing immense diversity in Ca2+ entry mediated by ligand-gated channels during synaptic transmission. Functional analysis of cloned channels allowed to identify structural elements in the pore forming regions determining Ca2+ permeability for many types of ligand-gated channels. The functional role of the Ca2+ entry mediated by various ligand-gated channels in mammalian central nervous system is less understood. The studies reviewed in this article provide information about known structural determinants of Ca2+ permeability of the ligand-gated channels and the role of this particular pathway of Ca2+ entry in cell function.

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Sprache(n): eng - English
 Datum: 1998-08-301998-09-212004-04-221998-11-01
 Publikationsstatus: Erschienen
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Titel: Cell Calcium
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Amsterdam, Netherlands : Churchill Livingstone
Seiten: - Band / Heft: 24 (5) Artikelnummer: - Start- / Endseite: 325 - 332 Identifikator: ISSN: 0143-4160
CoNE: https://pure.mpg.de/cone/journals/resource/954922647086